Radiopharmaceutical equipment of Granova Center for Radiology and Surgical Technologies

2021: Ministry of Industry and Trade allocates 125 million rubles for the development of radiopharmaceutical equipment

As it became known in early May 2021, the Ministry of Industry and Trade approved the application of the Federal State Budgetary Institution "Russian Scientific Center for Radiology and Surgical Technologies named after A.M. Granova" for the development of a drug for radionuclide therapy. 125 million rubles will be allocated for this project.

We are talking about the development of a long-acting radiopharmaceutical preparation (FPM) based on the encapsulated radionuclide rhenium-188. Details of the project are not disclosed.

It is only known that radiopharmaceuticals based on rhenium-188 were developed by Pharmsynthesis (Zoleren) for the therapy of bone metastases, rheumatoid arthritis and other neo-oncological joint diseases, as well as the MRNC named after A.F. Tsyba and the Medradiopreparat plant for palliative therapy of skeletal bone lesions. Both FPM have passed clinical trials by May 2021.

The Ministry of Industry and Trade allocates 125 million rubles to the Russian Scientific Center for Radiology and Surgical Technologies named after A.M. Granova for the development of radiopharmaceutical equipment

In the world practice of radionuclide therapy, rhenium-188 radionuclide-based drugs are used in various oncological diseases: bone metastases, hepatocellular carcinoma and metastatic liver damage, in skin tumors, outside oncology for radiosynvectomy in rheumatic diseases, in hemophilic arthropathy, for the treatment of keloid lesions, as well as in cardiac.

Preparations based on the radionuclide rhenium-188 (188Re) are promising in world nuclear medicine due to the nuclear-physical properties of the radionuclide 188Re: a therapeutic effect in the tissue lesion zone is achieved due to 188Re beta radiation, and diagnosis of the distribution of the drug in the body is provided due to gamma radiation.

In addition to the Federal State Budgetary Institution "Russian Scientific Center for Radiology and Surgical Technologies named after A.M. Granova," 36 applicants filed applications for the right to receive grants in the form of subsidies to budgetary institutions for the development of drugs or medical products in 2021, but all of them were rejected. In total it was planned to provide grants for 2.6 billion rubles, however only the application was approved. ^[1]

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