BioDevek: Bioclay for the treatment of internal wounds

2021: Announcement of bioclea for the treatment of internal wounds

In early December 2021, specializing in medical technologies BioDevek released adhesive for biomaterials, which serves to seal internal wounds and incisions. The material is intended for nebulization through a catheter, and the main application of the technology is sealing after resection of colon polyps.

As of December 2021, after resection of polyps, surgeons can use clips to suture the resection site, which can make it difficult to heal the wound or not use sealant at all, which leads to the formation of an open wound associated with the risk of bleeding and other complications. This can lead to additional surgeries to correct the problem and causes difficulties for both the patient and the doctor. To solve this problem, the researchers improved this biomaterial so that it forms an instant seal at the site of the removed polyp immediately after removal from the catheter. The sealant has been optimized to provide a proper combination of mechanical properties and biocompatibility for a given application, but the adhesive can be modified for use elsewhere in the body.

BioDevek introduced biocles for the treatment of internal wounds

The composition of the material is critical to the formation of a proper biological reaction. Adhesive sealants are inherently designed for chemical and physical interaction with tissue surfaces, making it even more difficult to obtain a proper tissue reaction. Sealants must conform to the mechanical properties of the underlying fabrics to ensure their proper functioning. At the same time, the sealant must remain attached to the fabric to prevent leakage of the seam line after internal operations. Commercially available adhesive materials have high mechanical properties or sufficient biocompatibility, which forces doctors to choose between these two parameters. BioDevek is working to solve this problem by developing intelligent materials that meet both of these properties. The company believes that the development of these materials will increase the penetration of adhesive materials into the market, which has so far been limited due to suboptimal characteristics of existing products.

Incorrect wound closure can lead to leaks, such as bleeding after vascular surgery, leaking intestinal contents after gastrointestinal surgery, and leaking air after lung surgery in 30% of patients undergoing internal surgery. Such leakage can lead to the need for additional procedures and even emergency surgery, increasing the risk of possible infection and disrupting the overall healing time of the wound. Eliminating these complications and allowing the body to heal naturally reduces hospitalization time and reduces costs to patients and service providers. In addition to sutures and staples as of December 2021, there are no commercial biomaterials-based solutions for wound closure after internal surgeries, and this in turn puts patients around the world at high risk of delayed bleeding and increases the potential need for repeated surgery and possible blood transfusions. BioDevek have also developed an injection solution that can cover the anastomotic line between tissue and graft after cardiovascular surgery.

The material is designed to remain in place for one week after the resection of the polyp, but its residence time can be adjusted for each application by adjusting the composition. Degradation time can be programmed according to the rate of tissue healing, so that the material will provide protection while the tissue is still compromised and begin to resorb at the time when the wound fully forms and heals. ^[1]

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