UrFU: Sensor for gastritis and ulcers by saliva analysis

2022: Sensor Announcement

In mid-June 2022, it became known about the creation of a chemical sensor in Russia, which allows the analysis of saliva to determine gastritis and ulcer. This is the development of the Ural Federal University named after the first President of Russia B.N. Yeltsin (UrFU).

According to TASS in the press service of the Federal Program of the Ministry of Education and Science of Russia "Priority 2030," the created sensor determines the pH level in biological fluids at the molecular level. Analysis of the acidity of human saliva using such a sensor makes it possible to diagnose various diseases of the gastrointestinal tract at an early stage by a non-invasive method.

Russia has developed a sensor that determines the early stages of gastritis and ulcers from the analysis of saliva

The scientists created a fluorophore (this is the part of the molecule that gives it fluorescent properties) with strong and stable radiation, capturing the slightest pH fluctuations in biological fluids. The data appears in five to seven seconds. Moreover, the substance corresponds to the principles of "green chemistry" - that is, the reaction proceeds without by-products, in non-toxic solvents (in water), and with minimal use of active fragments.

It is noted that in 2015, UrFU specialists synthesized and studied more than 70 compounds, six of which approached a number of parameters, and one was ultimately selected as a fluorophore (a fluorescent chemical compound that can re-emit light under light excitation) and formed the basis of the sensor. This phenomenon is called "cold glow."

Modern fluorometric pH sensors are based on small organic molecules. As a rule, they are very sensitive and are able to determine the necessary analyte in very small concentrations, up to nanoconcentrations. At the heart of our sensor is a new connection. We introduced a fluorinated fragment, and this allowed us to obtain the necessary properties of molecules - photophysical, chemosensory, - explained Timofey Moseev, research engineer of the Department of Organic and Biomolecular Chemistry of UrFU.[1]

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