PULSED (Particles Uniformly Liquified and Sealed to Encapsulate Drugs)

2023: Nanotechnology Announcement

On April 3, 2023, American researchers at William Marsh Rice University announced the development of advanced technology for the automatic delivery of drugs for a long time.

Scientists say that patients often forget to take medicines or do not comply with the schedule prescribed by the doctor. This reduces the effectiveness of the treatment course and can lead to negative consequences. Therefore, various scientific teams are creating delivery systems for slow-release drugs.

Nanotechnology developed to automatically administer drugs every day

The new technology is called PULSED (Particles Uniformly Liquidated and Sealed to Encapsulate Drugs). The idea is to use high-precision 3D printing to create an array of more than 300 non-toxic biodegradable nanocylinders. They are small enough to be introduced into the patient's body with standard needles for subcutaneous injections. The cylinders themselves are made from a material called PLGA - a biocompatible polymer that is widely used in clinical medicine. By adjusting the composition of the substance, you can change the release profile of the encapsulated drug, allowing it to be released within a certain time interval - from 10 days to five weeks.

The main goal is to avoid the drug being released too quickly. The researchers are confident that they will be able to further modify the nanoparticles in such a way as to bring the drug elimination time to six months. This will improve the effectiveness of long-term therapy, which requires strict adherence to the course prescribed by the doctor. The technology can also be used for targeted delivery of the drug - for example, exactly to the malignant zone. In formations this case, the particles will remain where they were injected - until they dissolve and release the drug.^[1]

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