Nanoscalpel for liquid tumor therapy

2023: Product Announcement

Scientists from Krasnoyarsk, Tomsk and Vladivostok have created a magnetic nanoscalpel for targeted and minimally invasive microsurgery of intractable ascites tumors. This was announced at the end of April 2023 by the press service of the Federal Research Center "Krasnoyarsk Scientific Center of the SB RAS."

Its researchers, together with scientists from the Krasnoyarsk State Medical University, took a leading part in the development. There are two components in the nanoscalpel - molecules that recognize the tumor, and magnetic nanodiscs that can mechanically destroy a tumor cell in an alternating magnetic field.

Magnetomechanical surgery is one of the promising methods of radical resection of a tumor at the level of one cell, - says the Doctor of Biological Sciences, Head of the Laboratory of Digital Controlled Drugs and Theranostics of the Federal Research Center of the National Research Center of the SB RAS, head of the Laboratory of Biomolecular and Medical Technologies of the Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky Ministry of Health of Russia Anna Kichkailo.

According to her, the advantage of a new nanoscale surgical instrument is that it is able to selectively destroy single tumor cells. Anna Kichkailo says that magnetic disks are very promising designs for magnetomechanical destruction of tumor cells. Experiments with ascites carcinoma have shown the fundamental possibility of nanodiscs to target and destroy individual tumor cells. Thus, magnetomechanical surgery with a remotely controlled variable magnetic field "nanoscalpel" can become a promising technology for the therapy of ascites tumor and malignancies.

The developers tested the effectiveness of the nanoscalpel in laboratory experiments on Ehrlich ascitic carcinoma cells and in mice. Studies have confirmed the effectiveness of magnetomechanical surgery using a nanoscalpel remotely controlled by a low-frequency magnetic field. The number of cancer cells in the ascites tumor of mice decreased significantly even after a single exposure.^[1]

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