| Developers: | NUST MISIS (National Research Technological University) |
| Date of the premiere of the system: | June 2023 |
| Branches: | Pharmaceuticals, Medicine, Healthcare |
2023: Product Announcement
On June 22, 2023, Russian specialists from the University of Science and Technology MISIS (NITU MISIS) announced the development of a biocompatible bone-cartilage implant of the knee joint. It is expected that the proposed technology will improve the engraftability of the product.
It is noted that diseases of the knee joint are one of the main causes of disability in the adult population. According to estimates, in Russia, about 4.5 million people suffer from osteoarthritis of the knee joint by mid-2023, but the real number of patients can reach 15 million. In the absence of timely treatment, such lesions can lead to serious consequences. At the same time, the cartilaginous tissue of the joint, which suffers most from osteoarthritis, has a low level of regeneration due to its structure.
The peculiarity of the new domestic development lies in the use of two types of biocompatible materials. In particular, thermoplastic polyurethane filled with spheroids from chondrocytes - cells of cartilage tissue is used to replace cartilage tissue. At the same time, bone tissue is replaced by polylactide with hydroxyapatite filled with spheroids from oseoblasts, that is, bone cells. This combined approach is claimed to provide better engraftment of the implant and also contributes to an increase in the number of cells leading to tissue growth.
It is said that the materials used to create the implant are not cytotoxic: they are not capable of toxic effects on cells. Samples with a fill density of 80% showed the best cell adhesion. As a result of morphometric evaluation and study of the spreading kinetics, spheroids with a concentration of 10,000 cells per spheroid were selected. The next stages of the project will be the preparation of a patent and access to preclinical tests. Specialists of the N. N. Priorov National Medical Research Center for Traumatology and Orthopedics of the Ministry of Health of Russia became interested in the development.[1]
Notes
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