WSU: Hydrogel-based artificial vessels

2023: Product Announcement

On June 30, 2023, American researchers from Wayne University released the results of a work that studied the properties of artificially grown vessels based on different hydrogels. Experts have proposed a way to create stronger structures.

The advantage of tissue engineering is noted to be the reproduction of soft tissue mechanics for more efficient integration into natural organs. However, the problem lies in the insufficient strength of the resulting structures consisting exclusively of cells. To eliminate this drawback, scientists used a hydrogel-based coating. In particular, three compositions were studied - gelatin, fibrin and collagen. As a crosslinking component, genipine was used - a chemical compound found in the extract of gardenia fruits.

Diagram of the principle of operation of artificial vessels

It turned out that the hydrogel based on gelatin crosslinked with genipine shows the highest tensile strength. However, in this case, it is not possible to form an optimal environment for cell reproduction. At the same time, a fibrin hydrogel without genipin was most suitable due to its good mechanical strength while maintaining cell viability. Scientists have concluded that vessels coated with fibrin hydrogel show the highest tensile strength. To further improve the properties, the effect of adding fibroblasts, connective tissue cells that form an extracellular matrix, to hydrogel coatings was studied.

Traditionally, rigid structures are used to ensure the necessary strength in soft tissue engineering, but they create a significant difference in mechanical properties compared to natural tissue. The new technology eliminates this drawback.^[1]

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