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RiGinaM (intestinal diagnostic technology)

Product
Developers: First Moscow State Medical University named after I.M. Sechenov (First Moscow State Medical University)
Date of the premiere of the system: September 2024
Branches: Pharmaceuticals, Medicine, Healthcare

2024: Technology Development

A new RiGinaM technology has been developed and began to be used in Russia, which allows diagnosing the intestinal condition without using colonoscopy. This became known at the end of August 2024. The innovative technique is already being used in experimental mode in the laboratory of Sechenov University in cooperation with the German clinic "Charite" and is aimed at diagnosing inflammatory diseases.

According to the press service of Sechenov University, RiGinaM technology is based on the on-site ribosomal hybridization (FISH) method. This method allows you to identify and track the activity of various microorganisms in the intestine without extracting them from the natural environment. According to the head of the laboratory, Professor Alexander Svidzinsky, the key advantage of the technology is the ability to visualize bacteria located in the intestines and observe their interaction with each other. Bacteria are stained with special tags that allow you to monitor their movement and activity under a microscope.


RiGinaM technology enables the diagnosis of diseases such as ulcerative colitis and Crohn's disease based on gut microbiota analysis. The advantage of the method is that it makes it possible to assess the degree of inflammation in real time, as well as monitor the effectiveness of the drugs used. Unlike colonoscopy, which is usually carried out once a year, this method allows doctors to quickly adjust treatment based on regular monitoring of the patient's condition.

In addition, RiGinaM technology can be used to diagnose colon cancer and other bowel diseases. Research plans to investigate whether some diseases previously thought to be autoimmune may actually be linked to bacterial activity. Polymicrobial infections caused by the interaction of multiple bacterial species are known to play a key role in the development of many diseases. In the future, this may allow a review of existing approaches to the treatment and diagnosis of such diseases.[1]

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