2020: Materials scientists "MISiS" presented antibacterial nano-coatings based on boron nitride
On September 9, 2020, it became known that materials scientists of NITU MISiS presented antibacterial nano-coatings based on boron nitride, which have effectiveness against microbial pathogens - up to 99.99%. They can become a safe alternative to the usual antibiotics in implantology, since they do not have characteristic negative side effects. The results of the work are presented in the international scientific journal ACS Applied Materials & Interfaces.
According to the company, as of September 2020, due to a significant increase in the number of surgical procedures around the world, scientists are solving the problem of microbial infections caused by implants. It is especially serious during orthopedic and dental operations. It is no secret that concomitant drug therapy of inflammation around implants often leads to side effects due to the characteristic properties of antibiotics, as well as its high doses.
A group of young scientists at NITU "MISiS" proposed a non-standard solution to the problem by investigating the interaction of antibiotic-resistant gram-negative bacteria Escherichia coli (E. coli) and a nanofilm consisting of a structured surface of boron nitride. It turned out that such a coating after 24 hours affects the 100% of bacterial cells.
 | Hexagonal boron nitride has a complex of physicochemical and mechanical properties. As a result of the experiments, we found that the special specific structure of boron nitride nanoparticles provides a bactericidal effect comparable to the action of an antibiotic: bacteria die as a result of direct physical contact with the special needle surface of the nano-film. At the same time, there are no side effects typical of the antibiotic on the body tissue, and boron nitride itself does not cause cytotoxicity. said Christina Hudz, co-author of the study, researcher at the laboratory "Inorganic Nanomaterials" NITU "MISiS" |  |
The researchers went further, and filled the micro-pores of a thin coating of boron nitride with the antibiotic gentamicin. As a result, an antibacterial effect was obtained due to the complete release of the drug in a short initial period of time. At the same time, its dose was an order of magnitude less than with a regular injection.
| | Taking into account the average patient weight of 60 kg, its daily dose of antibiotic is approximately 180 mg; provided that the implant area is, for example, 30 cm2 and considering that 55 μg of antibiotic is released from the tested nano-coating on the first day, it turns out that the proposed method involves 100 times less antibiotic than with standard injection. added Christina Hudz, co-author of the study, researcher at the laboratory "Inorganic Nanomaterials" NITU "MISiS" | |
According to the authors of the development, the application of an antibacterial film based on boron nitride nanoparticles on the implant can minimize the risk of bacterial infection due to the physical properties of the surface itself, as well as - in the case of antibiotic modification - local delivery of a minimum amount of the bactericidal component without weighting the implant.
As of September 2020, the team is completing studies of the obtained coatings in vitro, and is also working on optimizing the coating method for its promising use.
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