Kombivichvak (vaccine against HIV)

2020

Vector declared 100 percent efficiency of vaccine against HIV

In December, 2020 the state scientific center of virology subordinated to Rospotrebnadzor and biotechnology Vector announced results of the first phase of clinical trials of the vaccine against the human immunodeficiency virus (HIV). Affirms that the medicine which received the name "Kombivichvak" could develop antibodies to a virus at all participants of a research.

HIV-specific antibodies and cytotoxic T-lymphocytes after double vaccination the antibodies neutralizing VICh-psevdovirusy — at 80% were recorded at 100% of volunteers — told Interfax in Vector.

Pseudo-viruses call the modified virus particles which are identical to pathogenic viruses, however are biologically safe. Besides, security of vaccine for the person was confirmed.

The Russian developer of vaccine against HIV declared Institute of medical biotechnology Vector its 100 percent efficiency

On the Kombivichvak platform of Vector developed an advanced prototype of medicine – "Kombivichvak-Novo". Its efficiency against HIV can be defined in further clinical trials.

The preventive vaccine against HIV/AIDS is polieptopny, i.e. contains small fragments of the main virus proteins which are highly conservative for three VICh-1 subtypes (And, In and C), noted in Vector.

Advantages of poliepitopny vaccines are that they include only fragments of virus proteins, necessary for formation of specific immunity, do not support full-size structures of a virus which can be factors of pathogenicity in the structure and/or can inhibit formation of protective immunity or stimulate development of autoimmune reactions, – specified in scientific center.

Developers say that the activity of antibodies in new option of vaccine of Vector against HIV is ten times higher, than in initial. For completion of development it is necessary to conduct researches and to register vaccine.

According to the State Register of Medicines, Vector received permission to clinical trial of vaccine in 2013 and it will last till 2021. 240 volunteers from a medical medical unit of FMBA and the infectious center which are in the Novosibirsk region participate in tests.^[1]

Russia created prototypes of vaccine against HIV

On December 1, 2020 the head of Rospotrebnadzor Anna Popova at opening of the Federal scientific and methodical center for prevention and fight against AIDS announced creation in Russia of prototypes of vaccines against the human immunodeficiency virus (HIV). According to her, several Russian research centers, including the state scientific center (SSC) of virology and biotechnology Vector are engaged in development of medicines. GNTs also developed test systems for diagnosis of HIV.

Russia takes part in development of vaccine against HIV infection enough years, we have prototypes, we have vaccines — Popova told, at the same time without having called even approximate terms of readiness of medicines for carrying out inoculations.

In Russia prototypes of vaccine against HIV appeared

According to the Deputy Prime Minister Tatyana Golikova, the budget for provision of medicines of HIV-positive people is increased: in 2020 it made 27.2 billion rubles, and in the 2021st it will make 29.4 billion rubles. She noted that by the beginning of December, 2020 in the Russian Federation increase in prices for medicines for patients with HIV is not observed, and antiretroviral therapy is received by all persons in need.

By the World day of fight against AIDS (on December 1) the Federal State Statistics Service (Rosstat) published information on spread of HIV in Russia. According to department, in the Russian Federation became significantly more rare to fix new cases of infection of HIV — their number was reduced by 36%. In 2015, 33 patients with the diagnosed HIV were the share of one million Russians, and in 2019 this indicator decreased to 21.

The immunologist Vladimir Bolibok explains falling of number of new cases of HIV with decrease in a share of youth in structure of the population. According to the doctor, for the first time the disease usually comes to light at youth, and HIV-positive citizens of more advanced ages already know the status.^[2]

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