Geroprotectors
Heroprotectors are a common name for a group of substances in respect of which the ability to increase the life expectancy of animals has been found. Heroprotectors have a positive effect on the quality of life of organisms, including increasing life expectancy and resistance to stress, reducing the development rate of various age-related diseases, etc.
Main article: Aging
2016: Russian scientists have created a program to find a cure for old age
In early December 2016, it became known that Russian scientists from the Moscow Institute of Physics and Technology (MIPT) developed the GeroScope algorithm to search for means that increase life expectancy.
GeroScope was created to test geroprotectors in conjunction with Insilico Medicine, commissioned by the Center for Biogerontology and Regenerative Medicine.
GeroScope allows you to compare changes in the cells of young and old patients and search for drugs with minimal side effects that compensate for these changes.[1]
The algorithm modeled molecular pathways and did an analysis of the cell's responses to different substances. Based on the new algorithm, 10 substances were selected, and then the scientists examined human connective tissue stem cell lines to understand the effects of "rejuvenating" cells and prolonging viability.
By selecting from a database of geroprotective drugs tested on animals, 70 compounds scientists using a new algorithm identified among them 10, which, according to GeroScope, most effectively blocked sequences of reactions associated with aging.
 | For computer modeling, this is a very good result. In the pharmaceutical industry, 92% of drugs that have been tested in animals fail in clinical trials. Being able to model biological effects with such precision is a breakthrough. PD-98059 and NAC have shown themselves to be the strongest geroprotectors. We hope that some of these drugs will be tested in humans in the near future using biologically significant biomarkers of aging, - commented Alexander Zhavoronkov, Ph.D., Ph.D., Head of the Laboratory of Regenerative Medicine at the Federal Research Center for Pediatric Hematology, Oncology and Immunology named after D. Rogacheva, Associate Professor at MIPT, Head of Insilico Medicine (Center for Breakthrough Technologies, Johns Hopkins University) |  |
Notes
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