Gipereozinofilny syndrome (HEPS)
The hydroelectric power station is group of the rare diseases which are characterized by high content (≥ 1500 cages / mkl) eosinophils (a kind of leukocytes) in blood and body tissues which can cause the progressing damage of any body and, in case of lack of treatment, lead to a lethal outcome.
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Pathogenesis
Most often at hydroelectric power station skin, heart, lungs, digestive tract and the central nervous system is surprised.
Symptoms of the HEPS
Symptoms of the HEPS can include cough, fever, increased fatigue, bronchial asthma, the complicated breath, the whistling rattles, recurrent upper respiratory tract infections, belly-ache, vomiting, diarrhea, skin rash, arthritis, muscular pains and joint pain.
Therapy purpose
The purposes of therapy of the HEPS are a depletion of eosinophils in blood and body tissues, prevention of damage of bodies and deceleration of progressing of a disease. Though some patients with hydroelectric power station have an anomaly of a gene of a receptor of a trombotsitarny factor of growth (PDGFR) which increases their sensitivity to tyrosinekinase inhibitor to an imatinib, methods of treatment of patients at which the mutation of PDGFR is absent are limited, have different efficiency and are connected with development of the undesirable phenomena.
2019: Positive influence of a benralizumab on patients with a gipereozinofilny syndrome
Application of a benralizumab can lead to almost complete depletion of eosinophils and improvement of clinical results at patients with a gipereozinofilny syndrome (HEPS). It was shown in phase research II which data are published in the New England Journal of Medicine magazine, Zdrav.Expert in Astrazeneka company reported on April 29, 2019. Read more here.
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