Precise Bio

History

2025: Implantation of a 3D-printed cornea into a human

On October 29, 2025, the Rambam Medical Center (Haifa, Israel) underwent an innovative operation to implant the world's first three-dimensional bioprinted cornea. The patient over 70 years old, who suffered blindness due to corneal damage, partially restored her vision after transplantation of an artificial implant.

The technological breakthrough was reported by the Jerusalem Post. The cornea was created by the Israeli company Precise Bio using human cells. Bioprinting allows hundreds of transplants to be produced from a single donor sample.

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Фото: jpost.com

While more than 13 million people in the world expect a corneal transplant, the technology offers a scalable solution to the global shortage of donor corneas.

According to Precise Bio, the technology has three key advantages:

• artificial cornea free of contaminants;
• high cell density improves healing and visual function;
• standardized quality and predictability of results are guaranteed.

The head of the cornea department at the Rambam medical center, Professor Michael Mimuni, confirmed that the operation went well and that the patient's vision had already begun to improve. The team continues to closely monitor its recovery. Precise Bio co-founder and CEO Arie Butt called the operation a "historic moment," "the first case of successful use of a fully laboratory implant from human cells."

The head of ophthalmology at Jerusalem's Shaarei-Tzedek medical center and medical adviser to Precise Bio, David Tzadok, said the implant was the result of nearly a decade of research. According to him, doctors and engineers have achieved reproduction of the main properties of the natural cornea, which is critical "for long-term results and reducing the risks of complications."

According to Professor Eitan Livni, head of the cornea department at the Rabin medical center, the technology will revolutionize countries that lack corneal banks, returning sight to thousands of people.^[1]

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