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Biography
2024
Pig's genetically modified kidney transplant
On March 21, 2024, U.S. researchers at Massachusetts General Hospital (MGH) reported performing the first-ever operation to transplant a genetically modified pig kidney into a living human. The patient was 62-year-old Richard Slayman, who was diagnosed with end-stage organ disease.
It is reported that the operation, which lasted approximately four hours, was successful. This procedure marks an important milestone in the desire of physicians to provide patients with more accessible donor organs. To increase compatibility, pernicious genes of the animal were removed from the pig genome and certain human genes were added. In addition, scientists inactivated endogenous retroviruses in a donor pig to eliminate any risk of human infection. A total of 69 genomic changes have been made.
 | The success of this method is the culmination of the efforts of thousands of scientists and physicians over several decades. We are honored to play a significant role in such a significant event. We hope that this approach to transplantation will be a lifeline for millions of patients around the world suffering from kidney failure, "says Tatsuo Kawai, MD, one of the participants in the operation. |  |
Sleiman has been living with type two diabetes and hypertension for many years. He received a kidney transplant from a deceased human donor in December 2018, but the organ showed signs of failure about five years later. The man was transferred to dialysis in May 2023, which significantly worsened his quality of life. Therefore, Sleiman agreed to a transplant of a genetically modified pig kidney. It is noted that the patient's recovery process proceeds without complications, and soon he will be discharged from the hospital.[1]
Death
On May 11, 2024, the Massachusetts Clinical Hospital reported the death of the world's first patient to receive a gene-modified pig kidney transplant. Richard Slayman died at the age of 62 - about two months after the operation.
Massachusetts Clinical Hospital announced the world's first successful genetically modified pig kidney transplant in March 2024. Sleiman, who suffered from severe kidney failure, received the organ in a four-hour operation. It said the procedure carried out "marks an important milestone in the effort to provide patients with more accessible organs."
| | The success of this transplant is the culmination of the efforts of thousands of scientists and physicians over several decades. We are honored to play a significant role in this momentous event. We hope that this approach to transplantation will be a lifeline for millions of patients around the world suffering from kidney failure, the medical institution said in a statement. | |
The kidney was provided by Cambridge-based eGenesis from a pig that was genetically modified to remove genes harmful to the human recipient and add certain human genes to improve compatibility. In addition, scientists inactivated endogenous retroviruses to rule out any risk of infection.
| | The transplant team is deeply saddened by Rick Sleiman's sudden passing. We have no indication that this was the result of a recent transplant, "the medical institution said in an official statement. | |
After the transplant, Sleiman said one of the reasons he underwent the procedure was to give hope to thousands of people who need surgery like this to survive.[2]
Notes
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