| Developers: | Indian Science Institute (IISc) |
| Date of the premiere of the system: | August 2025 |
| Branches: | Pharmaceuticals, Medicine, Healthcare |
| Technology: | Robotics |
2025: Product Announcement
Specialists from the Center for Nanoscience and Engineering at the Indian Institute of Science (IISc) have developed innovative CalBot nanorobots designed to combat tooth hypersensitivity by blocking dentine tubes at the microscopic level. The new technology is about 400 nanometer diameter iron oxide nanoparticles with calcium and silicate-based bioceramic coatings that are controlled by an external magnetic field for precise positioning inside dental channels. Tests on remote human teeth and laboratory animals confirmed the effectiveness of the method in creating long-term protection against pain. This became known on August 18, 2025.
According to New Atlas, hypersensitivity of teeth occurs due to microscopic dentine tubes that penetrate dentin and lead directly to nerve endings inside the tooth. In normal condition, these channels are protected by tooth enamel, but when this protection is violated, hot, cold, acidic or sweet substances penetrate the tubes and cause a sharp pain.
CalBot technology is based on the principle of magnetic control of nanoparticles to create physical barriers inside dentine channels. The particle size is about one thousandth of the thickness of a human hair, which allows them to freely penetrate the microscopic cavities of dental tissue.
The procedure for using nanorobots begins with the application of particles to the surface of the affected tooth. The outer magnet directs the nanoparticles inside the dentine tubes, where they line up in ordered chains under the influence of a magnetic field.
Inside dental canals, CalBot particles form cement-like plugs up to half a millimeter long. These microscopic barriers perform a function similar to tooth enamel, blocking irritants from accessing nerve endings and preventing pain.[1]
Notes
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