| Developers: | First Moscow State Medical University named after I.M. Sechenov (First Moscow State Medical University) |
| Branches: | Pharmaceuticals, Medicine, Healthcare |
2025: Product Announcement
The Institute of Regenerative Medicine of Sechenov University has completed the first stage of creating an innovative tissue-engineering bioreactor. In February 2025, scientists presented a bioreactor cell that ensures the maturation of bone tissue and ligaments.
According to Sechenov University, the development is being carried out within the framework of the Organ-on-Order megaproject with the support of a grant from the Ministry of Science and Higher Education of Russia No. 075-15-2024-640.
Daria Revokatova, a researcher at the Institute of Regenerative Medicine, said that mesenchymal stem cells used to create tissue engineering constructs respond differently to surrounding factors. Mechanical stimuli, including compression and stretching, are required to form bone tissue, she said.
The new bioreactor is equipped with an automatic sensor system that provides monitoring of environmental parameters. It implements the function of automated replacement of the culture medium, which allows you to maintain optimal conditions for cell cultures. The equipment is designed to cultivate different types of tissues, and the multi-cell structure of the structure makes it possible to create complex bioequivalents.
The created cell uses a special membrane to form a periodontal ligament. In parallel, a compression module is being developed to create bone tissue.
In Russia, there are no analogues to such a bioreactor, and the only foreign analogue has limited functionality and requires manual control of most processes.
The system is equipped with automatic monitoring of key parameters including pH level, oxygen and carbon dioxide concentration. Mechanisms are also provided for regulating the supply of nutrient medium and utilization of waste components, which ensures process stability and optimal conditions for cell cultures.
The researchers plan to refine the technology for stretching and compression, improve the system for controlling environmental parameters and create combined modules for the simultaneous cultivation of several types of tissues.[1]
Notes
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