| Developers: | NUST MISIS (National Research Technological University) |
| Date of the premiere of the system: | 2024/11/05 |
| Branches: | Pharmaceuticals, Medicine, Healthcare |
Main article: Cancer diagnosis
2024: Introduction of a high-precision nanoelectrode sensor
NUST MISIS has developed a high-precision nanoelectrode sensor that can measure the concentration of copper ions in living cells and entire organs in real time. The development opens approaches in the diagnosis and analysis of the dynamics of cancer and hereditary diseases. In addition, the sensor will allow evaluating the effectiveness of new drugs containing copper. The university announced this on November 5, 2024.
Impaired copper metabolism in the body can lead to serious consequences, including cancer and Alzheimer's disease, Wilson-Konovalov, Menkes, etc. Detecting pathology in the early stages and analyzing its progression will help accurate detection of copper ions in cells, as well as assessing the ability of tissues and organs to accumulate copper-containing compounds.
It is impossible to carry out procedures with standard sensors without damaging body cells. NITU MISIS researchers solved this problem by developing a universal nanoscale electrochemical sensor for accurate quantitative detection of copper not only in individual cells, but also in 3D models of malignancies, real tumors and entire organs.
 | Copper imbalance can cause or result from serious disorders in the body. This sensor allows you to detect the concentration of metal ions faster and more accurately than analogs. Due to the size of the nanoelectrode, the procedure is minimally invasive and safe for living objects, "said Alexander Erofeev, Ph.D., head of the laboratory of biophysics at NUST MISIS. |  |
The sensor consists of nanoscale capillaries - hollow quartz tubes modified with carbon, gold and copper bonding compound. The principle of operation is based on the electrochemical reaction of oxidation and reduction of copper, read using cyclic voltammetry. Details of the work are published in the scientific journal Analytical Chemistry (Q1).
| | The nanoelectrode will help more accurately diagnose the disease and analyze the dynamics of treatment. In addition, with the help of a sensor, you can indirectly assess the effectiveness of antitumor, antifungal and antimicrobial drugs that contain copper, - said Roman Timoshenko, engineer of the scientific project of the laboratory of biophysics at NUST MISIS. | |
| | The team of researchers of the University of MISIS under the leadership of Ph.D., head of the laboratory of biophysics Alexander Erofeev for several years has been creating technologies for medicine, which in the future will simplify the diagnosis and treatment of various hereditary and oncological diseases. This high-precision sensor for measuring the level of copper in the body, developed by our scientists, has a number of advantages over existing analogues: it is more accurate, less invasive, provides more prompt results, - said the rector of NITU MISIS Alevtina Chernikova. | |
In the future, scientists plan to integrate the sensor into a full-fledged miniature device designed for long-term monitoring of metals in living organisms.
| The site content is translated by machine translation software powered by PROMT. The machine-translated articles are not always perfect and may contain errors in vocabulary, syntax or grammar. Read original article If you find inaccuracies or errors in the results of machine translation, please write to editor@tadviser.ru. We will make every effort to correct them as soon as possible. |