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2025: Proven: Popular sugar substitute erythritol destroys brain vessels
The popular sweetener erythritol has shown devastating effects on brain vessels. This conclusion was reached by specialists from the University of Colorado following a large-scale study published in June 2025. Scientists have recorded a direct link between erythritol consumption and impaired endothelial function - the layer of cells lining the inner surface of blood vessels. The authors of the work warn: regular use of this sugar substitute can increase risks to the cardiovascular system.
Experts conducted laboratory experiments with microvascular endothelial cells in the brain. Scientists exposed cell cultures to erythritol at a dose of six millimoles, which corresponds to the amount of sweetener in a standard diet drink.
Erythritol is a natural sweetener derived from natural sources and known as "melon sugar." The sweetness level of the substance is about 70% of the usual sugar, with a calorie content of 95% lower. The sweetener is widely used in the production of beverages, protein bars, desserts and sauces.
Consumers value erythritol for the lack of simple carbohydrates in the composition. The substance is not involved in the body's energy metabolism and does not stimulate insulin production when consumed, making it suitable for diabetics.
The experiment by American physiologists lasted three hours, after which the researchers measured markers of cellular function. The results showed alarming changes in the state of endothelial cells under the influence of a sugar substitute.
Erythritol-treated cells produced 75% more reactive oxygen species compared to control samples. These compounds are able to damage cellular components and increase oxidative stress, which can trigger the development of stroke.
Scientists recorded an increase in antioxidant proteins, suggesting cell attempts to counteract stress. However, the protective mechanisms did not fully cope with the negative effect of the sweetener.[1]
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