2023: Russian oncologists cure advanced cancer with new radiopharmaceutical
In September 2023, researchers from the Tomsk Research Institute of Oncology, TNIMC RAS presented the results of the successful treatment of stage four prostate cancer. Experts used the radiotherapy drug Lutetium-117 PSMA.
According to experts, this latest technology has made it possible to effectively fight cancer cells and metastases of castrate-resistant prostate cancer even after unsuccessful attempts by other treatments.
On the surface of the prostate is a special enzyme known as PSMA (prostate-specific membrane antigen). It was used by scientists as a target for targeted therapy. With the help of it, the radiopharmaceutical 177Lute purposefully attacked the tumor and metastases.
Prior to using this innovative method, the patient was found to have metastases in the liver, lymph nodes and bone tissue. All of them collected PSMA ligand - molecules that consist of amino acid residues that bind to the membranes of prostate cancer cells and deliver an isotope to them for the purpose of either diagnosis or therapy.
After four courses of treatment, the level of prostate-specific antigen (PSA) in the patient's blood decreased from 41 to 11 ng/ml. Follow-up studies also revealed a significant reduction in the rate of accumulation of PSMA ligand in metastases. The patient reported complete disappearance of pain syndrome and significant improvement in general condition.
Lutetium-177 (Lu-177) is one of the most promising radionuclides that serve as the basis for the production of innovative radiopharmaceuticals. According to experts, drugs with Lu-177 demonstrate high effectiveness in targeted therapy of a number of oncological diseases, among them metastatic forms of castration-resistant prostate cancer, neuroendocrine tumors, lung cancer and others. Lutetium-177 is obtained by irradiating targets in a reactor or on a cyclotron, but the growing global demand for this isotope forces us to look for new ways to obtain it.[1]
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