MISIS: Biodegradable plate with enzymes to prevent and treat tooth decay

Main article: Caries

2025: Introduction of a Biodegradable Thin Plate with Enzymes

Scientists at NUST MISIS have created a biodegradable thin plate with enzymes that helps not only prevent, but also treat the early stages of tooth decay. The project opens up prospects for the creation of a new generation of dental drugs that can significantly reduce the prevalence of tooth decay and increase the level of prevention of dental diseases. The university announced this on September 16, 2025.

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Фото: NITU MISIS

According to medical statistics, dental caries in patients increased by 640 million cases from 1990 to 2019, and more than 2 billion people suffer from severe periodontal diseases. Traditional dental drugs often do not work effectively enough: they only temporarily contact enamel, poorly repair microcracks, do not contain antibacterial components and have a limited therapeutic effect, "said Kirill Kucheryaev, co-author of the development, graduate student of NUST MISIS.

Researchers at NUST MISIS for the prevention and therapeutic effect in the early stages of tooth decay have proposed a solution to the problem - a biodegradable gelatin-based membrane that contains a mineral component - hydroxyapatite, which strengthens enamel, as well as a complex of enzymes for destroying plaque.

The material will be produced in the form of thin plates, which are easily fixed on the surface of the teeth. The patient will be able to use them on his own: the membrane will remain on the enamel and gradually dissolve, providing a controlled release of active substances. This technology increases the time of contact with the teeth and prolongs the therapeutic effect.

The key advantages of the new agent will be biocompatibility, the absence of side effects, prolonged action, antibacterial activity and the possibility of large-scale production using simple and inexpensive technology, - explained K. Kh. N. Ekaterina Chikanova, associate professor of the Department of General and Inorganic Chemistry.