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Liver cancer
2024: Russian scientists prove benefit of Thai herbal medicine in fight against liver cancer
NUST MISIS In confirmed the assumption of university scientists - Thailand Srinakharinvirot and Mahidol - that the Thai grass harvest Benja-Ummarit causes death. cancer cells medical that This was reported to the portal Zdrav.Expert on October 1, 2024 by representatives of MISIS. The results of the study open up new possibilities in the development of more effective ones. drugs to fight cancer liver
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According to Alexander Erofeev, Ph.D., Ph.D., head of the research laboratory of biophysics at NITU MISIS, the effectiveness of benja-ummarite on tumor cell models was proved using the scientific installation "Scanning ion-conducting microscope with confocal module."
 | "Although MISIS is not a medical university, the advanced equipment of the Institute of Biomedical Engineering allows us to conduct knowledge-intensive research for specialists who develop new drugs and treatments," the expert added. |  |
Benja-ummarit is often prescribed by Thai doctors practicing traditional methods of medicine as adjunctive therapy for the treatment of liver, bile duct or colon cancer. There are studies in the scientific literature reporting the devastating effects of herbal harvesting on tumor cells both in vitro and in vivo.
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Sorafenib is one of the most widely used drugs for the treatment of late-stage HCC, but it increases overall survival by less than 3 months. The problem is that during the administration of the drug in the patient's body, resistance to apoptosis develops - the process of death of cancer cells, on which the action of the drug is based, explained in MISIS.
| | "Ferroptosis, a regulated cell death based on the accumulation of iron and reactive oxygen species in them, can reduce drug resistance. This leads to the oxidation of lipids - a group of substances that provide energy, and then to a violation of their integrity. Benja-ummarit just launches such a process, "explained Nikita Savin, engineer of the research laboratory of biophysics at NITU MISIS. | |
Scientists investigated the mechanism of death of cancer cells and found that during the destruction process, their morphology changes, and the level of reactive oxygen species in them increases. Thus, it was possible to prove that benja-ummarite has useful properties. Details of the study are described in the scientific journal Journal of Ethnopharmacology (Q1).
The study was carried out within the framework of the federal project "Development of large-scale scientific and scientific and technological projects in priority research areas" of the national project "Science and Universities" (No. 075-15-2022-264).
2023: Innovative technology developed to treat carcinoma
On May 30, 2023, the medical company ABK Biomedical announced the development of an advanced technology for the treatment of unresectable hepatocellular carcinoma, the most common primary malignant tumor of the liver. Read more here.
2021
TheraSphere Y-90 Announcement - Liver Cancer Treatment Systems
In mid-March 2021 Boston Scientific , she introduced a new device for treatments cancer the liver. According to a press release, glass microspheres TheraSphere Y-90 have been developed to treat patients with hepatocellular carcinoma (HCC). More. here
Start of clinical trials of a method for treating liver cancer with microbubbles
In early January 2021, the results of the world's first clinical trial became known, which is considering a method of treating primary liver cancer with microbubbles. These small gas bubbles, surrounded by a lipid sheath, enter the liver and burst under the influence of ultrasound, destroying tumor cells.
| | This approach has shown its effectiveness in preclinical studies using animal models of other solid tumors such as bladder, prostate and breast cancers. This work shows for the first time the safety and effectiveness of this method in humans, "explained principal investigator John Eisenbrey. | |
Many patients with advanced cancer are recommended transarterial radioembolization, in which radioactive granules are injected into the blood vessels of the liver, and the radiation emitted by them destroys the tumor. However, the extent to which rays penetrate liver tissue is limited, and the tumor response to treatment is highly dependent on the distance to the radioactive granules. By combining transarterial radioembolization with the administration of microbubbles, doctors will be able to reduce the dose of radiation required to kill the tumor and increase the effectiveness of treatment.
When an ultrasonic wave hits the microbubbles, they begin to vibrate, and if the wave is strong enough, they burst. The clean energy of these tiny explosions causes physical and chemical damage to the blood vessels of tumors, making them more sensitive to radiation. By directing ultrasound to exactly where the tumor is located, doctors will be able to blow up microbubbles directly at the place where the radioactive granules are located, thereby ensuring localized sensitization of tumor cells and their final destruction.[1]
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