Diabetes mellitus
Main article: Diabetes mellitus
Diabetes treatment
Main Article: Diabetes Management
Blood glucose measurement systems
Main article: Blood glucose monitoring systems
Test strips for glucometers
Main article: Test strips for glucometers
Insulin pumps
Main article: Insulin pumps
Artificial pancreas
Main article: Artificial pancreas
Chronicle
2024
World's smallest insulin plaster pump released
At the end of October 2024, Luna Diabetes introduced the world's smallest insulin pump to monitor glucose levels at night. The Luna system in the form of a patch works in conjunction with a continuous glucose monitoring device, which allows you to calculate and inject fast-acting insulin microdoses during sleep, preventing unnecessary fluctuations both in that and in the other direction. Read more here.
A device has been released that continuously monitors glucose levels according to ECG data
In mid-October 2024, Singular Wings Medical announced the development of a compact device that allows continuous monitoring of glucose levels according to electrocardiogram (ECG) data. The novelty is expected to help improve the quality of life of people with diabetes. Read more here.
Smart insulin developed that automatically lowers blood sugar
In mid-October 2024, scientists introduced a new form of insulin that can automatically turn on and off depending on blood glucose levels. In animal studies, this "smart" insulin effectively reduced high blood sugar concentrations, preventing values from falling too low.
For people with diabetes, controlling blood sugar is important and challenging. Insulin allows you to reduce blood glucose levels, preventing many long-term complications. However, excess insulin can lead to an excessive decrease in blood glucose, that is, hypoglycemia, which is fraught with other complications, including fatal ones, and even mild to moderate hypoglycemia can cause weakness and confusion. In people with diabetes mellitus, especially type 1 DM, who constantly require insulin, a drop in blood glucose concentration can be noted up to several times a week, significantly worsening the quality of life.
The researchers solved this problem by modifying the insulin itself. They added a "switch" consisting of two parts: a ring structure known as a macrocycle and a glucoside, a molecule derived from glucose. When blood glucose concentration is low, glucoside binds to the ring, keeping insulin in a closed, inactive state. But when blood glucose levels rise, it displaces glucoside and changes the shape of insulin, "including" its effects.
The researchers tested the insulin molecule, which they named NNC2215, on pigs and rats. NNC2215 was not inferior in effectiveness to conventional human insulin, but prevented excessive decrease in blood glucose levels. Novo Nordisk, which funded the study, said researchers are continuing to optimize the molecule. In addition, several similar drugs are in development that could create a competitive environment in the future and ensure the availability of smart insulin for all patients.[1]
New diabetes therapy ReCET introduced, after which 86% of patients stopped taking insulin
In mid-October 2024, researchers from the University of Amsterdam announced the development of a new method for treating type 2 diabetes, which can significantly reduce or even eliminate the need for insulin. The therapy was called ReCET. Read more here
Meizu launches smart ring that monitors blood sugar
At the end of September 2024, the Chinese company Meizu introduced the StarV Ring 2 smart ring with functions for tracking vital signs of the body. The novelty, in particular, is able to determine blood sugar levels and assess the risk of hyperglycemia with an accuracy of 80%. Read more here
A device for continuous blood glucose control has been released, which can not be removed for two weeks
At the end of August 2024, Dexcom released the Stelo biosensor for continuous glucose monitoring, which can be worn without taking off for two weeks. Dexcom became the first company to receive regulatory approval to sell an over-the-counter glucose monitoring tool, the second was the company that released the Libre Rio over-the-counter device. Read more here.
Wearable Glucose Meter That Controls Blood Sugar 24/7 Launched
In mid-September 2024, Abbott launched the world's first continuous glucose monitoring system, Lingo, which is available to patients without a prescription. The Lingo system is based on FreeStyle Libre technology, which is already used by more than 6 million people with diabetes. Read more here
Hundreds of Americans with diabetes injured by leaky insulin pump management app
On May 8, 2024, the US Food and Drug Administration (FDA) reported that the company's mobile application Tandem Diabetes Care for working with insulin pumps contains errors that could harm the health of patients. Injuries provoked by this problem were reported by more than 200 people by the specified date. Read more here.
Shoe insoles have been created specifically for diabetics. They help avoid amputations
On April 19, 2024, American specialists from the University of Texas at Arlington Research Institute (UTARI) announced the development of special shoe racks designed for diabetics. Regular use of the products is claimed to reduce the risk of amputation of the lower extremities due to diabetic foot syndrome.
Scientists note that the probability of developing a diabetic foot during life in people with diabetes mellitus ranges from 19% to 34%. This is a severe complication, characterized by ulcerative-necrotic damage to joints and bones, as well as destruction of deep tissues due to impaired blood microcirculation. Diabetic foot develops against the background of degradation of nerve fibers and endings. Without the necessary therapy, such ulcers can lead to amputation of the limb and, as a result, to disability.
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It is estimated that in the United States alone, more than 160 thousand amputations of the lower extremities are carried out annually due to complications caused by diabetic foot ulcers. Such surgical interventions cost the American health care system about $30 billion annually. The ailment leads to a serious deterioration in the quality of life of patients and is often the cause of premature death. The insoles developed by UTARI specialists are designed to partially solve the problem.
The principle of operation of the product is a cyclic change in pressure in different sections of the foot. This reduces the load on soft tissue and improves blood flow, which reduces the likelihood of necrosis. The insoles contain special air chambers, for pumping and bleeding of which the pneumatic control unit is responsible. The parameters of the system are adjusted according to the anatomical characteristics and weight of the patient.[2]
Elta built a plant for the production of smart glucometers for 2.2 billion rubles
In April 2024, the Elta company completed the construction of a glucose meter plant in the Moscow Technopolice SEZ. The volume of investments in this project exceeded 2.2 billion rubles. Read more here.
Genetically modified cows start giving milk for diabetics
On March 13, 2024, American experts from the University of Illinois at Urbana-Champaign reported that they had managed to breed genetically modified cows capable of producing milk for diabetics. It is expected that this achievement in the future will help solve the problem of insulin deficiency on a global scale. Read more here.
2023
Subcutaneous implant for diabetics is presented. It injects insulin
On July 31, 2023, researchers from the Swiss Higher Technical School of Zurich (ETH Zurich) reported the creation of genetically modified human cells that produce insulin when stimulated by a weak electric current. In the future, this achievement can be used to develop more effective treatments for type 1 diabetes. Read more here.
Holographic glasses have been developed for the diagnosis of diabetic foot. They will help reduce the number of lower limb amputations
On June 28, 2023, Australian researchers from the University of Adelaide reported on the development of mixed reality glasses with holographic functions for medical professionals. This headset with accompanying software is expected to help treat leg and foot wounds in people with diabetes and vascular disease in remote and hard-to-reach regions. Read more here.
In Russia, developed a smart patch for the delivery of the body drugs from diabetes
At the St. Petersburg State Electrotechnical University "LETI" developed a smart patch for the delivery of drugs for diabetes to the body. A miniature electronic device introduces drugs using special microneedles without injuring the skin, the press service of the university said in June 2023. Read more here.
Insulin system for diabetics released that works almost entirely automatically
On May 22, 2023, Beta Bionics announced the release of the iLet Bionic Pancreas system for diabetics. This is said to be the first solution on the market that can almost completely automate the calculation of the dosage of insulin and the process of its supply to the body. Read more here.
Implant designed that turns excess blood glucose into electricity
On March 28, 2023, researchers from the Swiss Higher Technical School of Zurich (ETH Zurich) reported the development of an implantable fuel cell that converts excess blood glucose into electricity. In combination with artificial insulin-releasing beta cells, a system can be created to autonomously maintain the required blood sugar levels in people with type 1 diabetes.
In patients with this ailment, the body does not produce enough insulin (or does not produce it at all). Therefore, this hormone must be delivered from the outside - using injections or insulin pumps. The new method proposed by ETH Zurich scientists may become a more convenient alternative to traditional approaches.
Proposed fuel cell comprises anode with copper-based nanoparticles. In the device, glucose is split to generate electricity, which drives the electrical circuit. The fuel cell is connected to a capsule containing artificial beta cells: they can be stimulated to produce and secrete insulin using an electric current. As a result, the patient receives the necessary hormone.
The system is designed so that the fuel cell produces electric current only when the blood glucose level exceeds a certain threshold. As soon as the insulin produced reduces the blood sugar level to the desired value, the generation of electricity stops. The implant is coated with a special algae-based material approved for medical use.
The researchers say the fuel cell can produce enough electricity to communicate with a smartphone or other external appliance - this could give users and doctors the ability to monitor the device remotely using a companion app.[3]
Named the 11 most promising developers of technologies for the control and treatment of diabetes
At the end of March 2023, a list of the most promising startups specializing in creating technologies and services for the control and treatment of diabetes was released.
It is noted that innovative solutions are constantly being introduced in the field of diabetes therapy - from systems for continuous glucose monitoring to insulin pumps and artificial pancreas. The rating presented by the Drug Delivery Business News resource includes 11 young companies whose developments can help improve the quality of life of patients with different types of diabetes.
DiabetesWise
This California firm has created a free online service that provides tools to study the characteristics of diabetic devices that have received regulatory approval. Healthcare professionals can pick up the best solution available on the market for their patients.
Diatech Diabetes
The Memphis, Tennessee-based company offers SmartFusion infusion monitoring software. It detects the failure of insulin delivery and gives an idea of how the intensity of infusion affects the treatment of diabetes.
Glaice
The startup aims to combine knowledge in medical technology and healthcare with software, artificial intelligence and other advanced developments. The platform makes individual recommendations based on research and analysis of patient data.
GluCare
The Dubai-based company offers personalized care through a combination of digital therapy and a dedicated monitoring platform. The solution includes continuous metabolic tracking, data analysis, and expert support. The platform includes wearable devices.
HEAL.med
This British-based firm has created an educational app for children with type 1 diabetes. The program helps young patients to get information about their illness.
Medtech Concept
The Delaware-based company has developed a compact MiniPen 2 device to deliver insulin. This system has a low price, which makes it available to a wider range of people compared to the current large and expensive automatic injectors.
Open MedLabs
The Bangalore-based start-up specialises in designing and developing medical devices, including for diabetes, in resource-limited settings. The initiative will provide patients with access to advanced technologies at affordable prices.
The South Korean company is developing the OBM Rapid A1c product. This platform helps diabetics monitor their condition with HbA1c (glycated hemoglobin), a biochemical measure of blood that reflects the average blood sugar over a long period.
Replica Health
The company uses diabetic data to model metabolic responses in response to a variety of foods and activities. Machine learning tools allow you to get personalized information about the breakdown of carbohydrates.
Ryse Health
This company's platform includes continuous glucose monitoring facilities and a companion application. Together, these components generate data on the patient's condition and provide effective interaction with medical staff.
SmartStart Health
The British startup is developing a specialized SmartStart CGM application designed to simplify the use of continuous glucose monitoring tools for patients. SmartStart CGM integrates training and adaptation functions for simplicity and high efficiency.[4]
2022
In the Moscow region, the production of medical devices for diabetics is launched for 1 billion rubles
On October 24, 2022, it became known about the launch by Diakont of the production of test strips, glucose meters, glucose sensors and insulin pumps for monitoring blood sugar levels intended for patients with diabetes mellitus. Investments in the project are estimated at 1 billion rubles, it is being implemented with the assistance of the Moscow Region Development Corporation (KRMO). Read more here.
"Daughter" "Rostec" was chosen by the operator of the legal regime for remote monitoring of patients with diabetes and hypertension
"Daughter" "Rostec was chosen by the operator of the experimental legal regime (EPR) for remote monitoring of patients with diabetes and hypertension. This became known in early September 2022 from the relevant document. Ministry of Economic Development More. here
Wearable insulin pen for diabetics released
In early July 2022, CeQur introduced the Simplicity device, which is designed to make insulin administration as convenient as possible for people with diabetes. The company strives to make insulin therapy as convenient as possible, especially for those patients who prefer to independently manage insulin delivery. Read more here.
Created shoes for diabetics
On June 16, 2022, researchers from the Indian Institute of Science announced the creation of shoes that can independently regulate the distribution of pressure when walking, helping to avoid pain and friction, which can lead to complications in people with diabetes. Read more here.
Bigfoot Unity Smart Cap for Correct Insulin Dosage Calculation
In early May 2021, the first smart cap for insulin pen syringes was released. We are talking about the Bigfoot Unity product manufactured by Bigfoot Biomedical. It helps diabetic patients determine the correct insulin dosage. Read more here.
Medtronic Extended infusion kit for diabetics that can be worn for 7 days
In mid-April 2021, Medtronic released the world's first Medtronic Extended infusion kit for diabetics, which can be worn for up to 7 days. Thanks to this, patients will be able to safely use the insulin pump twice as long as usual. Read more here.
2021
Announcement of a device to stimulate the spinal cord for a serious complication of diabetes
In mid-July 2021, Nevro unveiled the world's first implantable spinal cord stimulation system, Senza, designed to treat chronic pain in diabetic neuropathy. Read more here.
Hypodermic Needle-Pro defective insulin syringe recall
In mid-June 2021, the American company Smiths Medical recalled its Jelco Hypodermic Needle-Pro fixed-needle insulin syringes. The recall was categorized as a Class 1 group because the disorders identified could threaten the life and health of patients. Read more here.
2020: Medtronic InPen Insulin Syringe Announcement
In early December 2020, as a result of the strategic acquisition of Companion Medical, Medtronic released a smart insulin pen for patients with diabetes mellitus who have to take several injections a day. Read more here.
2018: Online consultation service for diabetics launched by Online Doctor and Medtronic
On June 26, 2018, Online Doctor announced the launch of an online consultation service for diabetes patients. The company's partner in this project was the American manufacturer of medical devices Medtronic. Read more here.
Notes
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