National Medical Research Center named after Academician E.N. Meshalkin
Research Medical Organizations
Since 1957
Russia
Siberian Federal District of the Russian Federation
Novosibirsk
630055, st. Rechkunovskaya, 15
Owners
The National Medical Research Center named after Academician E.N. Meshalkin (FSBI National Medical Research Center named after E.N. Meshalkin of the Ministry of Health of Russia) is one of the largest multidisciplinary scientific, clinical and educational institutions of specialized medical care of the Ministry of Health of Russia.
History
2024
Start of production of long-lasting prostheses for children with heart defects
In early November 2024, the production of durable prostheses for children with heart defects began in Russia. In Novosibirsk, the Director General of the National Medical Research Center named after Academician E.N. Meshalkin of the Ministry of Health of Russia (Meshalkin Center) Alexander Chernyavsky announced the receipt of a registration certificate for a pulmonary artery prosthesis developed specifically for children with congenital heart defects.
According to Interfax, the conduit for the reconstruction of the exit department of the right ventricle in children received registration and is preparing for mass production. This prosthesis is intended for pediatric surgery, namely, to replace the pulmonary artery valve in severe congenital heart defects. According to Alexander Chernyavsky, the development is unique in that when creating it, materials with shape memory - nitinol are used, which allows you to form complex structures adapted to the characteristics of the child's body.
In
The Director General noted that the Meshalkin Center faced a number of technological challenges, in particular, the need to create technologies for heat treatment of nitinol, which are absent in Russia. To solve this problem, together with an industrial partner, new equipment was purchased, including a nitinol laser cutting machine worth ₽25 million, and production areas amounted to 700 square meters. m.
The developed pulmonary artery prosthesis is made from the jugular vein of a bull, which makes it especially resistant to calcium accumulation thanks to special treatment with epoxy and bisphosphate compounds. These features reduce the frequency of repeated operations. With existing technologies, prostheses must be changed a year after installation to a newborn, three years later - at preschool age, and five years later - in adolescence. The new development extends the life of the prosthesis to three years for newborns and up to 10 years for adolescents.[1]
Development of technology for preserving the life of the donor heart for 10 hours. Artificial lungs are used for this
In October 2024, Russian scientists talked about the creation of an innovative technology that allows, according to them, to maintain the viability of a donor heart outside the body for up to 10 hours. A key feature of the method is the use of artificial lungs, which significantly increases the transport time of the organ for transplantation.
According to the National Medical Research Center named after Academician E.N. Meshalkin, the development has no analogues in the world and is designed to solve the problem of delivering donor organs from remote regions of Russia. The technology of long-term normothermal conditioning of the donor heart allows you to overcome the limitations of the existing cold preservation method, in which the organ can be stored for no more than 4 hours.
Russia
The project manager, candidate of medical sciences Maxim Zhulkov said that at the first stage of research, the team managed to extend the functioning of the heart outside the body to 10 hours using the heart-lung complex. However, the gas exchange function of the lungs was depleted by the 5-6 hour, which made them unsuitable for self-transplantation.
To solve this problem, scientists modified the method by replacing the donor's own lungs with an oxygenator - artificial lungs. This made it possible to reliably prolong the working time of the heart outside the body in autoperfusion conditions and rationally use the donor resource.
The new technology also makes it possible to carry out a wide range of diagnostic procedures on the donor heart after its withdrawal, including coronarography, ultrasound diagnostics and magnetic resonance studies. This allows you to carefully assess the quality of the organ and eliminate the risk of using a poor-quality transplant.
Scientists have patented a couvez design for transporting a donor heart based on the new technology. Over the next three years, it is planned to develop a prototype of a domestic transport platform for a donor heart. [2]
Conducting the world's first operation to introduce heart rhythm driver cells
At the end of September 2024, the first operation in the world to implant artificially grown rhythm driver cells in the heart of an animal was carried out at the Academician Meshalkin National Medical Research Center (NMIC) in Novosibirsk. This unique achievement opens up new perspectives in the treatment of arrhythmia without the need to install electrocardiostimulants.
According to TASS, special rhythm driver cells, known as pacemakers, have the ability not only to contract, but also to generate and transmit control signals, regulating the rhythm of heart beats. The new technology allows these cells to be grown from a patient's blood cells and returned to the heart, thereby replacing artificial pacemakers with natural ones.
Project leader Alexander Romanov emphasized the importance of an animal experiment to confirm the effectiveness of the method in real conditions. Scientists were able to prove that the cells obtained in laboratory conditions are able to generate momentum regardless of the main rhythm of the beating heart.
Specialists from the Institute of Cytology and Genetics of the SB RAS and the MIPT laboratory engaged in the physics of bio-excitable systems participated in the development of the technology. They created a special biodegradation substrate that allows you to implant cells without damaging heart tissue.
During an experimental operation, a pig implanted pre-grown pacemaker cells in Moscow on a shrinking myocardium. A plate with cells measuring 1 cm by 1 cm was placed on the surface of the heart after making an incision of the chest and isolating a section of the heart muscle.
The experiment was successful: electrophysiological control devices recorded independent contractions in the desired area of the heart. In the future, scientists plan to apply the results of the project in clinical practice through the manufacture of "cell patches" that can point to myocardial areas with pathological rhythm, which is much less traumatic than surgical ablation of arrhythmia foci.[3]
Former clinic leaders received real terms for theft of 1.8 billion rubles
On April 15, 2024, a court in Novosibirsk sentenced the former head of the E.N. Meshalkin National Medical Research Center (NMIC) Alexander Karaskov to 3.5 years in a general regime colony and sentenced him to a fine of 800 thousand rubles in the case of embezzlement of 1.8 billion rubles. Read more here.
2023
For the first time in Russia, a prosthesis from pericardial tissues was created and used during heart surgery
For the first time in Russia, a prosthesis from pericardial tissues was created and used during heart surgery. This achievement was reported in September 2023 at the E. N. Meshalkin National Medical Research Center (NMIC). Read more here.
The court seized the apartment of the ex-head, who came out on parole
On April 6, 2023, the court issued a regular ruling against Yevgeny Nadezhalov, the former deputy director of the National Medical Research Center (NMIC) named after Ak. E.N. Meshalkin in Novosibirsk. Read more here.
The ex-deputy head of the clinic Meshalkin was released on parole. He was tried for embezzlement of 1.9 billion rubles
On March 14, 2023, the Pervomaisky District Court of Novosibirsk granted the petition for parole (parole) of the former deputy director of the National Medical Research Center (NMIC) named after Ak. E.N. Meshalkin in Novosibirsk Yevgeny Nadezhalov, sentenced to 2.5 years in prison in the case of large-scale embezzlement in the institution. Read more here.
2022
Performing a unique surgery to repair the pulmonary artery in a child
Doctors at the Meshalkin Center in Novosibirsk performed a unique operation to restore the pulmonary artery, and a small child needed surgery. This became known in August 2022.
The girl was born with a heart defect. There was a septal defect between the atria. The child was observed by a pediatrician at the place of residence in Perm. It was also planned to do an operation there, but a CT scan did not find a pulmonary artery feeding the left lung in a typical place and suggested its absence.
The baby's parents turned to Novosibirsk specialists for help. By this time, the girl began to quickly lose weight, get tired, blue nasolabial triangle was observed under loads.
The doctors of the Meshalkin clinic confirmed that the left pulmonary artery is absent, and the right one is seriously expanded due to the fact that throughout the life of the child all blood passed through it.
 | We found the germ of the open arterial duct (an embryonic vessel that normally closes in the first days of the child's life) also in an atypical place. In the practice of the cardiac surgery department of congenital heart defects, there was a patient with a similar vascular anomaly of the newborn period, in whom the pulmonary artery was interrupted but not yet finally closed. This experience suggested that the girl's left pulmonary artery still has, but is not visualized on multispiral computed tomography due to complete blockage, and the arterial duct is its beginning, - comments children's cardiovascular surgeon Alexei Viktorovich Voitov. |  |
The children decided to restore the patency of the left pulmonary artery. During a minimally invasive endovascular intervention, specialists passed the stump of the open arterial duct flowing into the narrowed left pulmonary artery with a conductor and expanded it with a balloon. When introducing a contrast agent, they saw the filling of the vessel with blood. In a second step, surgeons implanted a stent in the arterial duct to prevent the pulmonary artery from closing again.
The world specialized literature does not describe similar cases, experts say.[4]
Conducting the first surgery in Russia to treat arrhythmia on a "turned off" heart
Cardiac surgeons of the E. N. Meshalkin National Medical Research Center in Novosibirsk performed the first operation in Russia to treat arrhythmia on a "turned off" heart. This method was chosen because of the high risk of death of the patient during standard surgery for such pathology. Read more here.
Surgery to treat arrhythmia with microsecond pulses
Cardiac surgeons of the E. N. Meshalkin National Medical Research Center in Novosibirsk performed the first operation in Russia to treat arrhythmia with microsecond impulses. This was reported in the press service of the organization on June 27, 2022. Read more here.
2021
Ex-deputy director of the clinic Meshalkin received 2.5 years in prison for embezzlement of ₽1,9 billion
On November 3, 2021, the Central District Court of Novosibirsk sentenced to 2.5 years in prison the former deputy director of the National Medical Research Center (NMIC) of the Ministry of Health of the Russian Federation named after Academician Meshalkin Yevgeny Nadezhalov. A well-known cardiac surgeon was found guilty under Part 4 of Art. 160 of the Criminal Code of the Russian Federation (embezzlement using official position committed by an organized group on an especially large scale). In addition to imprisonment, he will have to pay a fine of 400 thousand rubles. Read more here.
Cardiac surgeons of the center performed the world's first operation on the aortic valve of the heart without a chest incision
Cardiac surgeons of the E. N. Meshalkin National Medical Research Center Novosibirsk performed the world's first valve operation aortas hearts without a chest incision. This was reported in the clinic in September 2021. More. here
2017: Renamed Meshalkin National Medical Research Center
July 12, 2017 became the National Medical Research Center named after Academician E.N. Meshalkin. Beyond the Urals, this is the only medical institution that has received national status.
2016
Reorganization into the Meshalkin Siberian Federal Biomedical Research Center
On November 28, 2016, the Novosibirsk Research Institute of Circulatory Pathology named after Academician E.N. Meshalkin was reorganized into the Siberian Federal Biomedical Research Center named after Academician E.N. Meshalkin.
The first operation on the abdominal aorta in Russia with a robot assistant
In November 2016, at the Novosibirsk Research Institute of Circulatory Pathology (NNIIPK) named after Academician E.N. Meshalkin, they performed the first operation on the abdominal aorta in Russia using a robot. This was reported on the website of the institution.
The da Vinci robotic surgical complex assisted in laparoscopic aorto-femoral bypass surgery - bypassing the affected aorta with a vascular prosthesis.
| | We performed a bypass bypass using a two-branch prosthesis, according to which blood from the healthy department of the abdominal aorta, bypassing the occluded department, enters the femoral arteries, - said Aleksey Arkhipov, candidate of medical sciences, head of the endovideosurgery group of the Research Institute. | |
Thanks to the robot, the risk of postoperative complications was reduced. With age, due to obesity and other age-related diseases, more of them may occur with open intervention. A mini-invasive operation involving a robot in such circumstances is the most optimal method of treatment, according to the NNIIPK.
Such cardiovascular operations are performed in a number of cardiac surgery centers due to technological difficulties. NNIIPK named after ACOD E.N. Meshalkina became the first center in the Russian Federation to develop the technology of laparoscopic operations using the da Vinci robot in vascular surgery.[5]
2010
As of March 2010, the Novosibirsk Research Institute of Circulatory Pathology named after ACOD E.N. Meshalkina Rosmedtehologii is the largest cardiac surgery center of the Ministry of Health and Social Development.
The main areas of activity: treatment of congenital and acquired heart defects, coronary heart disease, heart failure, diseases of the main and peripheral vessels, heart rhythm disorders, etc.
2008: Assignment of academician E.N. Meshalkin
In 2008, the Institute was named after the founder of academician E.N. Meshalkin.
The 1980th
By the late 1980s, the Institute had become a comprehensive medical center. By this time, patients are provided with the full amount of assistance: from comprehensive examination to surgery and rehabilitation, return to a full life.
The 1970th
In the late 70s, the Ministry of Health built a separate building for the Institute, the team scattered among various Novosibirsk hospitals gathered together again.
1963-64: Name change to Research Institute of Circulatory Pathology
In 1963-1964 the institution was transferred to the Ministry of Health of the RSFSR and changed its name to the Research Institute of Circulatory Pathology.
1957: Education
The Institute of Experimental Biology and Medicine was created in 1957 in Novosibirsk among the first institutions of the Siberian Branch of the USSR Academy of Sciences.
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