Institute of Molecular Biology named after V.A. Engelhardt RAS
Since 1993
Russia
Central Federal District of the Russian Federation
Moscow
119991, st. Vavilova, d. 32
Owners
History
2025: Participating in the development of a way to overcome the resistance of an aggressive brain tumor to chemotherapy
Scientists have found that enhancer RNA -- a short sequence that regulates STAT3 gene activity -- plays a key role in shaping the resistance of the most aggressive brain tumor (glioblastoma) to the chemotherapeutic drug temozolomide. Experiments have shown that by "blocking" the production of this molecule, tumor cells become sensitive to treatment. This paves the way for the development of new methods of cancer therapy. The results of the study, supported by a grant from the Russian Science Foundation (RNF), are published in the journal Gene. The RPF announced this on February 21, 2025.
Scientists from the V.A. EngelhardtRAN Institute of Molecular Biology (Moscow) and colleagues proposed a safer approach - to act on regulatory (enhancer) RNA, which controls the level of the STAT3 protein. The authors examined RNA TMZR1-eRNA, a short sequence that is read near the STAT3 gene and regulates the synthesis of the protein of the same name from it. Read more here.
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